Newcastle Falcons will face Ospreys away in the European Challenge Cup round of 16 on Easter weekend.
The exact date, kick-off time and TV channel for the game in Wales will be confirmed in due course, with the matches taking place over April 2, 3 and 4.
The winner of that game will reach quarter-finals on the weekend of April 9, 10 and 11, where a trip to Leicester Tigers or Irish province Connacht awaits.
The tournament's format has been revised following a truncated pool stage which saw the last two games cancelled.
Newcastle's two games in the competition have seen them losing 33-20 at home to Cardiff Blues and winning 26-17 away at French club, Castres.