Newcastle Falcons fly-half Louie Johnson and prop Mark Dormer are both on the bench for England Under-20s against their Italian counterparts on Friday.
The game in Treviso kicks off at 7pm UK time, and is being shown live on the BBC iPlayer.
Johnson and Dormer both started in England Under-20s' opening game, when they were 41-24 winners against Scotland Under-20s in Edinburgh.
Falcons flanker Matt Deehan started for the Scots in that game, and he packs down at No.8 on Friday night when Scotland Under-20s travel to take on their Welsh couterparts.
The 8pm kick-off in Colwyn Bay is being shown live on S4C and on the BBC iPlayer.