Newcastle Falcons flanker Mark Wilson will win his 11th cap for England when they travel to face Wales in Saturday's Guinness Six Nations clash.
Wilson has played every minute of England's victories over Ireland and France, and lines up on the blind-side flank for Saturday's 4.45pm kick-off, which will be shown live in the UK on BBC TV.
Head coach Eddie Jones has made two changes to the starting XV following injuries to Chris Ashton (Sale Sharks) and Mako Vunipola (Saracens) with Exeter Chiefs pair Jack Nowell selected on the right wing and Ben Moon at loosehead prop.
Jones said: “England and Wales is always a big game. Intense rivals and there is the historical context to it, but for us it is our most important game because it is our next game and that is how we are treating it.
“Whenever you play against a Warren Gatland side you are playing against a side that is going to be very physical on the gain line. They are always very fit so you have to make sure you win the gain line and then find opportunities of where you are going to attack them.
“As you have read in the media, it’s all about Wales, we are playing potentially the greatest team ever. Their players are full of emotion and it’s the biggest game they are going to play in their lives. We have had a good week just focusing on ourselves and focusing on getting our preparation right.”
England starting XV (509 caps)
15 Elliot Daly (Wasps, 27 caps)
14 Jack Nowell (Exeter Chiefs, 31 caps)
13 Henry Slade (Exeter Chiefs, 19 caps)
12 Manu Tuilagi (Leicester Tigers, 29 caps)
11 Jonny May (Leicester Tigers, 42 caps)
10 Owen Farrell (Saracens, 67 caps - captain)
9 Ben Youngs (Leicester Tigers, 82 caps)
1 Ben Moon (Exeter Chiefs, 5 caps)
2 Jamie George (Saracens, 34 caps)
3 Kyle Sinckler (Harlequins, 19 caps)
4 Courtney Lawes (Northampton Saints, 70 caps)
5 George Kruis (Saracens, 29 caps)
6 Mark Wilson (Newcastle Falcons, 10 caps)
7 Tom Curry (Sale Sharks, 7 caps)
8 Billy Vunipola (Saracens, 38 caps)
Replacements (147 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 9 caps)
17 Ellis Genge (Leicester Tigers, 6 caps)
18 Harry Williams (Exeter Chiefs, 16 caps)
19 Joe Launchbury (Wasps, 55 caps)
20 Brad Shields (Wasps, 5 caps)
21 Dan Robson (Wasps, 1 cap)
22 George Ford (Leicester Tigers, 53 caps)
23 Joe Cokanasiga (Bath Rugby, 2 caps)